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No dose adjustment of Sildenafil Citrate is recommended. Sildenafil citrate increases the blood circulation in the reproductive organs of men. Magnesium hydroxide/aluminum hydroxide antacids: Single doses of antacid (magnesium hydroxide/aluminum hydroxide) did not affect the bioavailability of sildenafil. Single oral doses of sildenafil up to 100 mg produced no clinically relevant changes in the ECGs of normal male volunteers. This lower selectivity is thought to be the basis for abnormalities related to color vision observed with higher doses or plasma levels (see Pharmacodynamics). When used to treat erectile dysfunction, non-arteritic anterior ischemic optic neuropathy (NAION), a cause of decreased vision including permanent loss of vision, has been reported postmarketing in temporal association with the use of phosphodiesterase type 5 (PDE5) inhibitors, including sildenafil. Patients had a clinical diagnosis of type 1 diabetes of at least 1 year’s duration as defined by the National Diabetes Data Group (17) and had required insulin within 1 month of diagnosis.

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